CHOLINE - SCI & TECH
News: UQ research finds molecular
doorways to help deliver drugs into the brain
What's in the news?
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Recently, researchers made a discovery revealing
that a protein known as FLVCR2 facilitates the transportation of the essential
nutrient choline into the brain.
Choline:
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Choline is an essential nutrient crucial for
supporting various bodily functions, including cellular growth and metabolism.
Forms and Absorption:
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Choline exists in both water-soluble and fat-soluble forms, with the body
transporting and absorbing it differently based on its form.
Dietary Sources:
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While the body can produce small amounts of choline in the liver, it's insufficient
to meet daily requirements, necessitating dietary intake.
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Rich sources include meat, fish, dairy, eggs, as well as
fruits, vegetables, and whole grains.
Functions:
1. Cell Structure:
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Choline is a key component of phospholipids, such as lecithin, essential for cell membrane
integrity across plant and animal cells.
2. Methyl Group Source:
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It provides methyl groups crucial for various
metabolic processes.
3. Liver Health:
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Choline aids in clearing cholesterol from the
liver, preventing fat and cholesterol
buildup associated with nonalcoholic fatty liver disease.
4. Nervous System:
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Choline is essential for acetylcholine synthesis, a
neurotransmitter vital for memory,
muscle movement, and other nervous system functions.
5. Other Roles:
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It plays roles in gene expression, cell membrane
signaling, lipid metabolism, brain development, and acts as a food source for
beneficial gut bacteria.
Deficiency Implications:
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Choline deficiency can lead to health issues like
cardiovascular disease and muscular damage.